
|

|

|
| Medical Abstract Title: |
| |
Comparative Study Of Hormone
Replacement, Including Transdermal And Oral Bio-Identical
Natural Hormones And Homeopathic Hormone Stimulation And
Rejuvenation Using Salivary Testing As A Diagnostic Tool. |
| Author: |
| |
Theresa Dale, Ph.D.,
C.C.N., N.P.
Certified Clinical Nutritionist
Traditional Naturopathic Practitioner
BioEnergetic Medical Consultant
Dean & Founder, California College of Natural Medicine
President, The Wellness Center |
| Abstract: |
| METHODS: |
| |
Using a 24-hour circadian
salivary testing with specific testing times according
to Traditional Chinese Medicine Five Element Body Clock,
hundreds of saliva tests were analyzed. The factors used
in the analysis of hormonal ratios included age, medical
history of surgical procedures such as partial and/or
complete hysterectomies, genetics and any type of hormone
replacement usage. |
| |
All salivary testing was
administered the second day of the menstrual cycle or,
in the case of very infrequent menstruation or menopause,
testing was administered the second day of a month. |
| |
The following hormones
were analyzed: 6 cortisol levels at specific times related
to organ function, progesterone, testosterone, estradiol,
and DHEA levels. |
| |
Homeopathic hormone transdermal
therapy was administered according to test results for
a period of three, six or nine months with repeated salivary
testing to monitor results. |
| |
Homeopathic meridian therapy
was orally administered according to the meridian testing
times that were abnormal. |
| |
A dietary regime was also
administered to each client incorporating 60% raw whole
foods, eliminating chemicals, and preservatives, sugar,
caffeine, and alcohol. |
| RESULTS: |
| |
Approximately 550 salivary
tests were analyzed, and 95% of those clients using hormone
replacement had abnormal hormonal ratios. 96% of those
clients using bio-identical, synthetic or natural hormone
replacement had elevated progesterone levels and abnormal
ratios of other hormones such as cortisol, testosterone,
estradiol and/or DHEA. |
| |
Of the 96% of clients using
progesterone transdermal or oral replacement including
bio-identical, synthetic and natural hormones, approximately
40% of clients had extremely elevated progesterone (up
to 50 times greater than normal reference ranges). Clients
with high progesterone reported symptomology such as hair
loss, bloating, depression, insomnia, headaches, mood
swings and constipation. |
| |
85% of patients with elevated
salivary cortisol levels indicated a link to blood sugar
problems, such as diabetes and digestive disturbances. |
| |
After using homeopathic
hormone rejuvenation for three months, both to detoxify
excess progesterone and stimulate production of progesterone
and other hormones, symptoms improved in over 70% of cases
according to personal communication with patient and repeated
salivary test done by a licensed independent laboratory.
After using homeopathic formulas for an additional three
months, new saliva test results revealed even further
progress in balancing hormone ratios including cortisol
levels. |
| |
The remaining cases had
definite improvement but still chose to use some prescribed
hormone replacement and/or consumed an excess of alcohol,
sugar and caffeine. Approximately 20% of patients testing
did not indicate a need to continue homeopathic treatment
after only three months. |
| |
90% of patients, whose
salivary test results indicated a low DHEA level, resulted
in a definite increase in DHEA in three months when a
formula containing homeopathic cortisol, adrenal, hypothalamus
and pituitary was applied topically during specific days
of the monthly cycle. |
| |
Further salivary testing
within three months of usage of homeopathic meridian therapy
indicated that cortisol levels improved dramatically in
50% of patients. 45% of patients indicated moderate improvement
in most cortisol level testing times that were out of
balance. 5% of patients indicated minor improvement in
one to six cortisol-testing times. |
| CONCLUSIONS: |
| |
Progesterone and estrogen
replacement can be dangerous and create a toxic build-up
of hormones, even if monitored. |
| |
Hormone replacement has
side effects whether it is supposedly bio-identical
or even a wild yam transdermal and can cause abnormal
hormone ratios. |
| |
Hormone replacement will
cause the gland or organ that is responsible for specific
hormone production to slow down and eventually shut down
hormonal production. |
| |
Adrenal cortisol stress
can be the sole cause of hot flashes and other symptoms.
Cortisol in humans is the principal glucocorticoid and
it influences appetite and well-being, maintains blood
sugar concentrations by promoting hepatic gluconeogenesis,
and indirectly affects heart rate and pumping force by
controlling synthesis of epinephrine in the adrenal medulla.
Therefore, since increased cortisol secretion is critical
in the physiologic response to stress and illness, we
can see the value of utilizing six specific cortisol level
testing times to evaluate acupuncture meridian function.
|
| |
Elevated progesterone levels
from hormone replacement can cause adrenal stress, liver
toxicity, and abnormal hormonal ratios. |
| |
Homeopathy is the only
modality, thus far, that has shown the ability when formulated
for this purpose to stimulate cellular communication to
the hypothalamus and pituitary to make natural biological
hormones strengthening the biological terrain without
toxic side effects. |
| |
A diet with 60% raw unprocessed
food is an extremely valuable element in the release of
stress on the adrenal glands and assisting in the stabilization
of cortisol and glucose levels. |
| |
This research places hormone
replacement of any kind at a questionable disadvantage. |
| References |
| 1. |
Orth DN, Kovaks WJ, DeBold
CR: The adrenal cortex. William's Textbook of Endocrinology,
8th ed. Wilson JD, Foster DW, Eds. WB Saunders Co, Philadelphia,
1992, p 489 |
| 2. |
Meikle AW, Daynes RA, Araneo
BA: Adrenal androgen secretion and biologic effects. Endocrinol
Metab Clin North Am 20:381, 1991 [ 1831756] |
| 3. |
Quinn SJ, Williams GH:
Regulation of aldosterone secretion. Ann Rev Physiol 50:409,
1988 |
| 4. |
Orth DN: Corticotropin-releasing
hormone in humans. Endocr Rev 13:164, 1992 |
| 5. |
Watabe T, Tanaka K, Kumagae
M, et al: Role of endogenous arginine vasopressin in potentiating
corticotropin-releasing hormone-stimulated corticotropin
secretion in man. J Clin Endocrinol Metab 66:1132, 1988
[ 2836468] |
| 6. |
Salata RA, Jarrett DB,
Verbalis JG, et al: Vasopressin stimulation of adrenocorticotropin
hormone (ACTH) in humans. J Clin Invest 81:766, 1988 [
2830315] |
| 7. |
Iranmanesh A, Lizarralde
G, Short D, et al: Intensive venous sampling paradigms
disclose high frequency adrenocorticotropin release episodes
in normal men. J Clin Endocrinol Metab 71:1276, 1990 |
| 8. |
Dallman MF, Akana SF, Levin
N, et al: Corticosteroids and the control of function
in the hypothalamo-pituitary-adrenal (HPA) axis. Ann NY
Acad Sci 746:22, 1994 [ 7825879] |
| 9. |
Findling JW, Engeland WC,
Raff H: The use of immunoradiometric assay for the measurement
of ACTH in human plasma. Trends in Endocrinol Metab 1:283,
1990 |
| 10. |
Kaye TB, Crapo L: The Cushing
syndrome: an update on diagnostic tests. Ann Intern Med
112:434, 1990 |
| 11. |
Kannan CR: Diseases of
the adrenal cortex. DM 34:613, 1988 |
| 12. |
Seeler LR: Cushing's syndrome.
Cleve Clin J Med 55:329, 1988 |
| 13. |
Biller BMK, Alexander JM,
Zervas NT, et al: Clonal origins of adrenocorticotropin-secreting
pituitary tissue in Cushing's disease. J Clin Endocrinol
Metab 75:1303, 1992 |
| 14. |
Odell WD: Ectopic ACTH
secretion: a misnomer. Endocrinol Metab Clin North Am
20:371, 1991 |
| 15. |
Ulick S, Wang JZ, Blumenfeld
JD, et al: Cortisol inactivation overload: a mechanism
of mineralocorticoid hypertension in the ectopic adrenocorticotropin
syndrome. J Clin Endocrinol Metab 74:963, 1992 [ 1569172] |
| 16. |
Williams GH: Guardian of
the gate: receptors, enzymes, and mineralocorticoid function
(editorial). J Clin Endocrinol Metab 74:961, 1992 |
| 17. |
Belsky JL, Cuello B, Swanson
LW, et al: Cushing's syndrome due to ectopic production
of corticotropin-releasing factor. J Clin Endocrinol Metab
60:496, 1985 [ 2982899] |
| 18. |
King DR, Lack EE: Adrenal
cortical carcinoma: a clinical and pathologic study of
49 cases. Cancer 44:239, 1979 [ 455249] |
| 19. |
Malchoff CD, MacGillivray
D, Malchoff DM: Adrenocorticotropic hormone-independent
adrenal hyperplasia. Endocrinologist 6:79, 1996 |
| 20. |
Hermus AR, Pieters GF,
Smals AG, et al: Transition from pituitary-dependent to
adrenal-dependent Cushing's syndrome. N Engl J Med 318:966,
1988 |
| 21. |
Young WF Jr, Carney JA,
Musa BU, et al: Familial Cushing's syndrome due to primary
pigmented nodular adrenocortical disease: reinvestigation
50 years later. N Engl J Med 321:1659, 1989 |
| 22. |
Reznik Y, Allali-Zerah
V, Chayvialle JA, et al: Food-dependent Cushing's syndrome
mediated by aberrant adrenal sensitivity to gastric inhibitory
polypeptide. N Engl J Med 327:981, 1992 |
| 23. |
Lacroix A, Bolte E, Tremblay
J, et al: Gastric inhibitory polypeptide-dependent cortisol
hypersecretion-a new cause of Cushing's syndrome. N Engl
J Med 327:974, 1992 |
| 24. |
Bertagna X: New causes
of Cushing's syndrome (editorial). N Engl J Med 327:1024,
1992 |
| 25. |
Kreisberg R: Half a loaf.
N Engl J Med 330:1295, 1994 |
| 26. |
Findling JW: Clinical application
of a new immunoradiometric assay for ACTH. Endocrinologist
2:360, 1992 |
| 27. |
Snow K: Biochemical evaluation
of adrenal dysfunction: the laboratory perspective. Mayo
Clin Proc 67:1055, 1992 |
| 28. |
Flack MR, Oldfield EH,
Cutler GB Jr, et al: Urine free cortisol in the high-dose
dexamethasone suppression test for the differential diagnosis
of the Cushing syndrome. Ann Intern Med 116:211, 1992
29. |
| 30. |
Zarate A, Kovaks K, Flores
M, et al: ACTH and CRF-producing bron chial carcinoid
associated with Cushing's syndrome. Clin Endocrinol 24:523,
1986 |
| 31. |
Grossman AB, Howlett TA,
Perry L, et al: CRF in the differential diagnosis of Cushing's
syndrome: a comparison with the dexamethasone suppression
test. Clin Endocrinol 29:167, 1988 |
| 32. |
Nieman LK, Cutler GB Jr,
Oldfield EH, et al: The ovine corticotropin-releasing
hormone (CRH) stimulation test is superior to the human
CRH stimulation test for the diagnosis of Cushing's disease.
J Clin Endocrinol Metab 69:165, 1989 |
| 33. |
Schulte HM, Allolio B,
Gunther TK, et al: Bilateral and simultaneous sinus petrosus
inferior catheterization in patients with Cushing's syndrome:
plasma-immunoreactive-ACTH-concentrations before and after
administration of CRF. Horm Metab Res (suppl) 16:66, 1987 |
| 34. |
Loriaux DL, Nieman L: Corticotropin-releasing
hormone testing in pituitary disease. Endocrinol Metab
Clin North Am 20:363, 1991 |
| 35. |
Malchoff CD, Orth DN, Abboud
C, et al: Ectopic ACTH syndrome caused by a bronchial
carcinoid tumor responsive to dexamethasone, metyrapone,
and corticotropin-releasing factor. Am J Med 84:760, 1988
|
| 36. |
Gold PW, Loriaux DL, Roy
A, et al: Responses to corticotropin-releasing hormone
in the hypercortisolism of depression and Cushing's disease.
N Engl J Med 314:1329, 1986 |
| 39. |
Groote Veldman R, Meinders
AE: On the mechanism of alcohol-induced pseudo-Cushing's
syndrome. Endocr Rev 17:262, 1996 |
| 40. |
Prevalence of 3-hydroxysteroid
dehydrogenasedeficient nonclassic adrenal hyperplasia
in hyperandrogenic women with adrenal androgen excess
American Journal of Obstetrics and Gynecology September
1999 Volume 181 Number 3 Carlos Moran, MD, MS, H.
Downing Potter, BS, Rosario Reyna, BS, d, Larry R. Boots,
PhD, Ricardo Azziz, MD, MPH. |
| 41. |
1: J Nutr 2001 May;131(5):1621S-5S
Human saliva as a diagnostic specimen. Hofman LF. Saliva
Testing and Reference Laboratory, Inc., Seattle, WA 98104.
PMID: 11340128 [PubMed - in process] |
| 42. |
1: Endocr Res 2000 Nov;26(4):489-504
Fetal hypothalamic-pituitary adrenal (HPA) development
and activation as a determinant of the timing of birth,
and of postnatal disease. Challis J, Sloboda D, Matthews
S, Holloway A, Alfaidy N, Howe D, Fraser M, Newnham J.
Department of Physiology, University of Toronto, Ontario,
Canada.2PMID: 11196419 [PubMed - indexed for MEDLINE] |
| 43. |
Van Goozen SH, Weigant
VM, Endert E, Helmond FA, Van de Poll NE. Psychoendocrinological
assessment of the menstrual cycle: the relationship between
hor-mones, sexuality, and mood. Arch Sex Behav 1997;26(4):359-382.
|
| 44. |
Lee KA, Shaver JF, Giblin
EC, Woods NF. Sleep patterns related to menstrual cycle
phase and premenstrual affective symptoms. Sleep 1990;
13(5):403-409. |
| 45. |
Dye L, Blundell JE. Menstrual
cycle and appetite control: implications for weight regu-lation.
Hum Reprod 1997;12(6):1142-1151. |
| 46. |
Redei E, Freeman EW. Daily
plasma estradiol and progesterone levels over the menstrual
cycle and their relation to premenstrual symp-toms. Psychoneuroendocrinol
1995; 20(30):259-267. |
| 47. |
De Boever J, Kohen F, Bouve
J, Leyseele D,Vandekerckhove D. Direct chemilumines-cence
immunoassay of estradiol in saliva. Clin Chem 1990;36:2036-41. |
| 48. |
Wong Y, Mao K, Panesar
NS, Loong EP, Chang AM, Mi ZJ. Salivary estradiol and
prog-esterone during the normal ovulatory menstru-al cycle
in Chinese women. Eur J Obst Gynecol and Rep Biol 1990;34:129-35.
|
| 49. |
Vining R, McGinley R, and
Symons R. Hormones in saliva: mode of entry and conse-quent
implications for clinical interpretation. Clin Chem 1983;29:1752-56.
|
| 50. |
Bhagavan NV. Medical Biochemistry.
Boston: Jones and Bartlett Publishers; 1992, 805-807.
|
| 51. |
Vuorento T, Lahti A, Hovatta
O, and Huhtaniemi I. Daily measurements of salivary progesterone
reveal a high rate of anovulation in healthy students.
Scan J Clin Lab Invest 1989;49:395-401. |
| 52. |
Danutra V, Turkes A, Read
G, Wilson D, Griffiths V, Jones R, Griffiths K. Progesterone
concentrations in samples of saliva from ado-lescent girls
living in Britain and Thailand, two countries where women
are at widely differing risk of breast cancer. J Endocrin
1988; 121:375-81. |
| 53. |
Finn M, Gosling J, Tallon
D, Joyce L, Meehan F, Fottrell P. Follicular growth and
corpus luteum function in women with unexplained infertility,
monitored by ultrasonography and measurement of daily
progesterone. Gynecol Endocrin 1989;3:297-308. |
| 54. |
Vuorento T, Hovatta O,
Kurunmaki H, Ratsula K, Huhtaneimi I. Measurements of
salivary progesterone throughout the menstrual cycle in
women suffering from unexplained infertility reveal high
frequency of luteal phase defects. Fertil Steril 1990;54:211-16.
|
| 55. |
Vuorento T, and Huhtaniemi
I. Daily measure-ments of salivary progesterone during
men-strual cycle in adolescent girls. Fertil Steril 1992;58:685-90.
|
| 56. |
Wren B. Reproductive endocrinology.
In: Hacker N and Moore J., editors. Essentials of obstetrics
and gynecology. Philadelphia: W. B. Sanders Co., 1992.
|
| 57. |
Ronkainen H, et al. Physical
exercise-induced changes and season-associated differences
in the pituitary-ovarian function of runners and joggers.
J Clin Endocrin Metab 1985;60:416. |
| 58. |
Lipson S and Ellison P.
Normative study of age variation in salivary progesterone
profiles. J Biosoc Sci 1992;24:233-44. |
| 59. |
Hamilton C, Wetzels L,
Evers J, Hoogland H, Muijtjens A, de Haan J. Follicle
growth curves and hormonal patterns in patients with luteinized
unruptured follicle syndrome. Fertil Steril 1985;43:541-48. |
| 60. |
van Zonneveld P, te Velde
E, Koppeschaar H. Low luteal phase serum progesterone
levels in regularly cycling women are predictive of sub-tle
ovulating disorders. Gynecol Endocrin 1994;8:169-74. |
| 61. |
Ayers J, Birenbuam DL,
Menon KM. Luteal phase dysfunction in endometriosis: elevated
progesterone levels in peripheral and ovarian veins during
the follicular phase. Fertil Steril 1987;47:935-39. |
| 62. |
Wingfield M, OHerlihy
C, Finn M, Tallon D, Fottrell P. Follicular and luteal
phase salivary progesterone profiles in women with endometriosis
and infertility. Gynecol Endocrin 1994;8:21-25. |
| 63. |
Pirke KM, Schweiger U,
Laessle R, Dickhaut B, Schweiger M, Waechtler M. Dieting
influences the menstrual cycle: vegetarian versus nonvege-tarian
diet. Fertil Steril 1986;46:1083. |
| 64. |
Karmen B. Hormone replacement
therapy: yes or no? Novato, CA: Nutrition Counter, Inc.,
1993. |
| 65. |
Wilson D, Turkes A, Jones
R, Danutra V, Read G, Griffiths K. A comparison of menstrual
cycle profiles of salivary progesterone in British and
Thai adolescent girls. Eur J Cancer 1992; 28A:1162-67.
|
| 66. |
De Cree C, Lewin R, Ostyn
M. The monitoring of the menstrual status of female athletes
by salivary steroid determination and ultrasonog-raphy.
Eur J App Physiol 1990;60:472-77. |
| 67. |
Keizer H. Exercise- and
training-induced men-strual cycle irregularities (AMI).
Int J Sports Med 1986;8(suppl 3):137-74. |
| 68. |
Keizer H, Poortman J, Bunnick
G. Influence of physical exercise on sex steroid metabolism.
J Appl Physiol 1980;48:765-69. |
| 69. |
Wentz A. Cigarette smoking
and fertility. Fertil Steril 1986;46:365. 41A41
|
|
|