|
Hormone Assessment
|
|
Medical
Abstract Title:
|
|
|
Comparative
Study Of Hormone Replacement, Including Transdermal And Oral Bio-Identical
Natural Hormones And Homeopathic Hormone Stimulation And Rejuvenation
Using Salivary Testing As A Diagnostic Tool.
|
|
Author:
|
|
|
Theresa
Dale, Ph.D.
Dean
International College of Naturopathy
Naturopathic Physician
|
|
Abstract:
|
|
METHODS:
|
|
|
Using
a 24-hour circadian salivary testing with specific testing times according
to Traditional Chinese Medicine Five Element Body Clock, hundreds of saliva
tests were analyzed. The factors used in the analysis of hormonal ratios
included age, medical history of surgical procedures such as partial and/or
complete hysterectomies, genetics and any type of hormone replacement
usage.
|
|
|
All
salivary testing was administered the second day of the menstrual cycle
or, in the case of very infrequent menstruation or menopause, testing
was administered the second day of a month.
|
|
|
The
following hormones were analyzed: 6 cortisol levels at specific times
related to organ function, progesterone, testosterone, estradiol, and
DHEA levels.
|
|
|
Homeopathic
hormone transdermal therapy was administered according to test results
for a period of three, six or nine months with repeated salivary testing
to monitor results.
|
|
|
Homeopathic
meridian therapy was orally administered according to the meridian testing
times that were abnormal.
|
|
|
A
dietary regime was also administered to each client incorporating 60%
raw whole foods, eliminating chemicals, and preservatives, sugar, caffeine,
and alcohol.
|
|
RESULTS:
|
|
|
Approximately
550 salivary tests were analyzed, and 95% of those clients using hormone
replacement had abnormal hormonal ratios. 96% of those clients using
bio-identical, synthetic or natural hormone replacement had elevated progesterone
levels and abnormal ratios of other hormones such as cortisol, testosterone,
estradiol and/or DHEA.
|
|
|
Of
the 96% of clients using progesterone transdermal or oral replacement
including bio-identical, synthetic and natural hormones, approximately
40% of clients had extremely elevated progesterone (up to 50 times greater
than normal reference ranges). Clients with high progesterone reported
symptomology such as hair loss, bloating, depression, insomnia, headaches,
mood swings and constipation.
|
|
|
85%
of patients with elevated salivary cortisol levels indicated a link to
blood sugar problems, such as diabetes and digestive disturbances.
|
|
|
After
using homeopathic hormone rejuvenation for three months, both to detoxify
excess progesterone and stimulate production of progesterone and other
hormones, symptoms improved in over 70% of cases according to personal
communication with patient and repeated salivary test done by a licensed
independent laboratory. After using homeopathic formulas for an additional
three months, new saliva test results revealed even further progress in
balancing hormone ratios including cortisol levels.
|
|
|
The
remaining cases had definite improvement but still chose to use some prescribed
hormone replacement and/or consumed an excess of alcohol, sugar and caffeine.
Approximately 20% of patients testing did not indicate a need to continue
homeopathic treatment after only three months.
|
|
|
90%
of patients, whose salivary test results indicated a low DHEA level, resulted
in a definite increase in DHEA in three months when a formula containing
homeopathic cortisol, adrenal, hypothalamus and pituitary was applied
topically during specific days of the monthly cycle.
|
|
|
Further
salivary testing within three months of usage of homeopathic meridian
therapy indicated that cortisol levels improved dramatically in 50% of
patients. 45% of patients indicated moderate improvement in most cortisol
level testing times that were out of balance. 5% of patients indicated
minor improvement in one to six cortisol-testing times.
|
|
CONCLUSIONS:
|
|
|
Progesterone
and estrogen replacement can be dangerous and create a toxic build-up
of hormones, even if monitored.
|
|
|
Hormone
replacement has side effects whether it is supposedly bio-identical
or even a wild yam transdermal and can cause abnormal hormone ratios.
|
|
|
Hormone
replacement will cause the gland or organ that is responsible for specific
hormone production to slow down and eventually shut down hormonal production.
|
|
|
Adrenal
cortisol stress can be the sole cause of hot flashes and other symptoms.
Cortisol in humans is the principal glucocorticoid and it influences appetite
and well-being, maintains blood sugar concentrations by promoting hepatic
gluconeogenesis, and indirectly affects heart rate and pumping force by
controlling synthesis of epinephrine in the adrenal medulla. Therefore,
since increased cortisol secretion is critical in the physiologic response
to stress and illness, we can see the value of utilizing six specific
cortisol level testing times to evaluate acupuncture meridian function.
|
|
|
Elevated
progesterone levels from hormone replacement can cause adrenal stress,
liver toxicity, and abnormal hormonal ratios.
|
|
|
Homeopathy
is the only modality, thus far, that has shown the ability when formulated
for this purpose to stimulate cellular communication to the hypothalamus
and pituitary to make natural biological hormones strengthening the biological
terrain without toxic side effects.
|
|
|
A
diet with 60% raw unprocessed food is an extremely valuable element in
the release of stress on the adrenal glands and assisting in the stabilization
of cortisol and glucose levels.
|
|
|
This
research places hormone replacement of any kind at a questionable disadvantage.
|
|
References
|
| 1. |
Orth
DN, Kovaks WJ, DeBold CR: The adrenal cortex. William's Textbook of Endocrinology,
8th ed. Wilson JD, Foster DW, Eds. WB Saunders Co, Philadelphia, 1992,
p 489
|
| 2. |
Meikle
AW, Daynes RA, Araneo BA: Adrenal androgen secretion and biologic effects.
Endocrinol Metab Clin North Am 20:381, 1991 [ 1831756]
|
| 3. |
Quinn
SJ, Williams GH: Regulation of aldosterone secretion. Ann Rev Physiol
50:409, 1988
|
| 4. |
Orth
DN: Corticotropin-releasing hormone in humans. Endocr Rev 13:164, 1992
|
| 5. |
Watabe
T, Tanaka K, Kumagae M, et al: Role of endogenous arginine vasopressin
in potentiating corticotropin-releasing hormone-stimulated corticotropin
secretion in man. J Clin Endocrinol Metab 66:1132, 1988 [ 2836468]
|
| 6. |
Salata
RA, Jarrett DB, Verbalis JG, et al: Vasopressin stimulation of adrenocorticotropin
hormone (ACTH) in humans. J Clin Invest 81:766, 1988 [ 2830315]
|
| 7. |
Iranmanesh
A, Lizarralde G, Short D, et al: Intensive venous sampling paradigms disclose
high frequency adrenocorticotropin release episodes in normal men. J Clin
Endocrinol Metab 71:1276, 1990
|
| 8. |
Dallman
MF, Akana SF, Levin N, et al: Corticosteroids and the control of function
in the hypothalamo-pituitary-adrenal (HPA) axis. Ann NY Acad Sci 746:22,
1994 [ 7825879]
|
| 9. |
Findling
JW, Engeland WC, Raff H: The use of immunoradiometric assay for the measurement
of ACTH in human plasma. Trends in Endocrinol Metab 1:283, 1990
|
| 10. |
Kaye
TB, Crapo L: The Cushing syndrome: an update on diagnostic tests. Ann
Intern Med 112:434, 1990
|
| 11. |
Kannan
CR: Diseases of the adrenal cortex. DM 34:613, 1988
|
| 12.
|
Seeler
LR: Cushing's syndrome. Cleve Clin J Med 55:329, 1988
|
| 13. |
Biller
BMK, Alexander JM, Zervas NT, et al: Clonal origins of adrenocorticotropin-secreting
pituitary tissue in Cushing's disease. J Clin Endocrinol Metab 75:1303,
1992
|
| 14. |
Odell
WD: Ectopic ACTH secretion: a misnomer. Endocrinol Metab Clin North Am
20:371, 1991
|
| 15. |
Ulick
S, Wang JZ, Blumenfeld JD, et al: Cortisol inactivation overload: a mechanism
of mineralocorticoid hypertension in the ectopic adrenocorticotropin syndrome.
J Clin Endocrinol Metab 74:963, 1992 [ 1569172]
|
| 16. |
Williams
GH: Guardian of the gate: receptors, enzymes, and mineralocorticoid function
(editorial). J Clin Endocrinol Metab 74:961, 1992
|
| 17. |
Belsky
JL, Cuello B, Swanson LW, et al: Cushing's syndrome due to ectopic production
of corticotropin-releasing factor. J Clin Endocrinol Metab 60:496, 1985
[ 2982899]
|
| 18. |
King
DR, Lack EE: Adrenal cortical carcinoma: a clinical and pathologic study
of 49 cases. Cancer 44:239, 1979 [ 455249]
|
| 19. |
Malchoff
CD, MacGillivray D, Malchoff DM: Adrenocorticotropic hormone-independent
adrenal hyperplasia. Endocrinologist 6:79, 1996
|
| 20. |
Hermus
AR, Pieters GF, Smals AG, et al: Transition from pituitary-dependent to
adrenal-dependent Cushing's syndrome. N Engl J Med 318:966, 1988
|
| 21. |
Young
WF Jr, Carney JA, Musa BU, et al: Familial Cushing's syndrome due to primary
pigmented nodular adrenocortical disease: reinvestigation 50 years later.
N Engl J Med 321:1659, 1989
|
| 22. |
Reznik
Y, Allali-Zerah V, Chayvialle JA, et al: Food-dependent Cushing's syndrome
mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide.
N Engl J Med 327:981, 1992
|
| 23.
|
Lacroix
A, Bolte E, Tremblay J, et al: Gastric inhibitory polypeptide-dependent
cortisol hypersecretion-a new cause of Cushing's syndrome. N Engl J Med
327:974, 1992
|
| 24. |
Bertagna
X: New causes of Cushing's syndrome (editorial). N Engl J Med 327:1024,
1992
|
| 25. |
Kreisberg
R: Half a loaf. N Engl J Med 330:1295, 1994
|
| 26. |
Findling
JW: Clinical application of a new immunoradiometric assay for ACTH. Endocrinologist
2:360, 1992
|
| 27. |
Snow
K: Biochemical evaluation of adrenal dysfunction: the laboratory perspective.
Mayo Clin Proc 67:1055, 1992
|
| 28. |
Flack
MR, Oldfield EH, Cutler GB Jr, et al: Urine free cortisol in the high-dose
dexamethasone suppression test for the differential diagnosis of the Cushing
syndrome. Ann Intern Med 116:211, 1992 29.
|
| 30. |
Zarate
A, Kovaks K, Flores M, et al: ACTH and CRF-producing bron chial carcinoid
associated with Cushing's syndrome. Clin Endocrinol 24:523, 1986
|
| 31. |
Grossman
AB, Howlett TA, Perry L, et al: CRF in the differential diagnosis of Cushing's
syndrome: a comparison with the dexamethasone suppression test. Clin Endocrinol
29:167, 1988
|
| 32. |
Nieman
LK, Cutler GB Jr, Oldfield EH, et al: The ovine corticotropin-releasing
hormone (CRH) stimulation test is superior to the human CRH stimulation
test for the diagnosis of Cushing's disease. J Clin Endocrinol Metab 69:165,
1989
|
| 33. |
Schulte
HM, Allolio B, Gunther TK, et al: Bilateral and simultaneous sinus petrosus
inferior catheterization in patients with Cushing's syndrome: plasma-immunoreactive-ACTH-concentrations
before and after administration of CRF. Horm Metab Res (suppl) 16:66,
1987
|
| 34. |
Loriaux
DL, Nieman L: Corticotropin-releasing hormone testing in pituitary disease.
Endocrinol Metab Clin North Am 20:363, 1991
|
| 35. |
Malchoff
CD, Orth DN, Abboud C, et al: Ectopic ACTH syndrome caused by a bronchial
carcinoid tumor responsive to dexamethasone, metyrapone, and corticotropin-releasing
factor. Am J Med 84:760, 1988
|
| 36. |
Gold
PW, Loriaux DL, Roy A, et al: Responses to corticotropin-releasing hormone
in the hypercortisolism of depression and Cushing's disease. N Engl J
Med 314:1329, 1986
|
| 39. |
Groote
Veldman R, Meinders AE: On the mechanism of alcohol-induced pseudo-Cushing's
syndrome. Endocr Rev 17:262, 1996
|
| 40. |
Prevalence
of 3-hydroxysteroid dehydrogenasedeficient nonclassic adrenal hyperplasia
in hyperandrogenic women with adrenal androgen excess American Journal
of Obstetrics and Gynecology September 1999 Volume 181 Number 3 Carlos
Moran, MD, MS, H. Downing Potter, BS, Rosario Reyna, BS, d, Larry R. Boots,
PhD, Ricardo Azziz, MD, MPH.
|
| 41. |
1:
J Nutr 2001 May;131(5):1621S-5S Human saliva as a diagnostic specimen.
Hofman LF. Saliva Testing and Reference Laboratory, Inc., Seattle, WA
98104. PMID: 11340128 [PubMed - in process]
|
| 42. |
1:
Endocr Res 2000 Nov;26(4):489-504 Fetal hypothalamic-pituitary adrenal
(HPA) development and activation as a determinant of the timing of birth,
and of postnatal disease. Challis J, Sloboda D, Matthews S, Holloway A,
Alfaidy N, Howe D, Fraser M, Newnham J. Department of Physiology, University
of Toronto, Ontario, Canada.2PMID: 11196419 [PubMed - indexed for MEDLINE]
|
| 43. |
Van
Goozen SH, Weigant VM, Endert E, Helmond FA, Van de Poll NE. Psychoendocrinological
assessment of the menstrual cycle: the relationship between hor-mones,
sexuality, and mood. Arch Sex Behav 1997;26(4):359-382.
|
| 44. |
Lee
KA, Shaver JF, Giblin EC, Woods NF. Sleep patterns related to menstrual
cycle phase and premenstrual affective symptoms. Sleep 1990; 13(5):403-409.
|
| 45. |
Dye
L, Blundell JE. Menstrual cycle and appetite control: implications for
weight regu-lation. Hum Reprod 1997;12(6):1142-1151.
|
| 46. |
Redei
E, Freeman EW. Daily plasma estradiol and progesterone levels over the
menstrual cycle and their relation to premenstrual symp-toms. Psychoneuroendocrinol
1995; 20(30):259-267.
|
| 47. |
De
Boever J, Kohen F, Bouve J, Leyseele D,Vandekerckhove D. Direct chemilumines-cence
immunoassay of estradiol in saliva. Clin Chem 1990;36:2036-41.
|
| 48. |
Wong
Y, Mao K, Panesar NS, Loong EP, Chang AM, Mi ZJ. Salivary estradiol and
prog-esterone during the normal ovulatory menstru-al cycle in Chinese
women. Eur J Obst Gynecol and Rep Biol 1990;34:129-35.
|
| 49. |
Vining
R, McGinley R, and Symons R. Hormones in saliva: mode of entry and conse-quent
implications for clinical interpretation. Clin Chem 1983;29:1752-56.
|
| 50. |
Bhagavan
NV. Medical Biochemistry. Boston: Jones and Bartlett Publishers; 1992,
805-807.
|
| 51. |
Vuorento
T, Lahti A, Hovatta O, and Huhtaniemi I. Daily measurements of salivary
progesterone reveal a high rate of anovulation in healthy students. Scan
J Clin Lab Invest 1989;49:395-401.
|
| 52. |
Danutra
V, Turkes A, Read G, Wilson D, Griffiths V, Jones R, Griffiths K. Progesterone
concentrations in samples of saliva from ado-lescent girls living in Britain
and Thailand, two countries where women are at widely differing risk of
breast cancer. J Endocrin 1988; 121:375-81.
|
| 53. |
Finn
M, Gosling J, Tallon D, Joyce L, Meehan F, Fottrell P. Follicular growth
and corpus luteum function in women with unexplained infertility, monitored
by ultrasonography and measurement of daily progesterone. Gynecol Endocrin
1989;3:297-308.
|
| 54. |
Vuorento
T, Hovatta O, Kurunmaki H, Ratsula K, Huhtaneimi I. Measurements of salivary
progesterone throughout the menstrual cycle in women suffering from unexplained
infertility reveal high frequency of luteal phase defects. Fertil Steril
1990;54:211-16.
|
| 55. |
Vuorento
T, and Huhtaniemi I. Daily measure-ments of salivary progesterone during
men-strual cycle in adolescent girls. Fertil Steril 1992;58:685-90.
|
| 56. |
Wren
B. Reproductive endocrinology. In: Hacker N and Moore J., editors. Essentials
of obstetrics and gynecology. Philadelphia: W. B. Sanders Co., 1992.
|
| 57. |
Ronkainen
H, et al. Physical exercise-induced changes and season-associated differences
in the pituitary-ovarian function of runners and joggers. J Clin Endocrin
Metab 1985;60:416.
|
| 58. |
Lipson
S and Ellison P. Normative study of age variation in salivary progesterone
profiles. J Biosoc Sci 1992;24:233-44.
|
| 59. |
Hamilton
C, Wetzels L, Evers J, Hoogland H, Muijtjens A, de Haan J. Follicle growth
curves and hormonal patterns in patients with luteinized unruptured follicle
syndrome. Fertil Steril 1985;43:541-48.
|
| 60. |
van
Zonneveld P, te Velde E, Koppeschaar H. Low luteal phase serum progesterone
levels in regularly cycling women are predictive of sub-tle ovulating
disorders. Gynecol Endocrin 1994;8:169-74.
|
| 61. |
Ayers
J, Birenbuam DL, Menon KM. Luteal phase dysfunction in endometriosis:
elevated progesterone levels in peripheral and ovarian veins during the
follicular phase. Fertil Steril 1987;47:935-39.
|
| 62. |
Wingfield
M, OHerlihy C, Finn M, Tallon D, Fottrell P. Follicular and luteal phase
salivary progesterone profiles in women with endometriosis and infertility.
Gynecol Endocrin 1994;8:21-25.
|
| 63. |
Pirke
KM, Schweiger U, Laessle R, Dickhaut B, Schweiger M, Waechtler M. Dieting
influences the menstrual cycle: vegetarian versus nonvege-tarian diet.
Fertil Steril 1986;46:1083.
|
| 64. |
Karmen
B. Hormone replacement therapy: yes or no? Novato, CA: Nutrition Counter,
Inc., 1993.
|
| 65. |
Wilson
D, Turkes A, Jones R, Danutra V, Read G, Griffiths K. A comparison of
menstrual cycle profiles of salivary progesterone in British and Thai
adolescent girls. Eur J Cancer 1992; 28A:1162-67.
|
| 66. |
De
Cree C, Lewin R, Ostyn M. The monitoring of the menstrual status of female
athletes by salivary steroid determination and ultrasonog-raphy. Eur J
App Physiol 1990;60:472-77.
|
| 67. |
Keizer
H. Exercise- and training-induced men-strual cycle irregularities (AMI).
Int J Sports Med 1986;8(suppl 3):137-74.
|
| 68. |
Keizer
H, Poortman J, Bunnick G. Influence of physical exercise on sex steroid
metabolism. J Appl Physiol 1980;48:765-69.
|
| 69. |
Wentz
A. Cigarette smoking and fertility. Fertil Steril 1986;46:365. 41A41
|
|
|
Wellness Center
| Resource Center
| Int'l College of Naturopathy
| Shopping
Contact
| Menopause Symptoms Home Page
© 2003-04, Wellness Center
|