Hepatic Glutathione Pathway Formula

by Theresa Dale in Health Provider Content, Health Provider Protocols Lecture Handouts and Training Manual, Member Bonus Section, Member Content, Products

Dr. Dale’s Hepatic Glutathione Pathway Formula New Formulation!

Our HGP Orthomolecular formula addresses detoxification in so many ways. We have reformulated to include the best form of Folate and Selenium available and changed the important ingredient quantity to act synergistically. This will enable the HGP formula to act faster and offer the maximum bioavailability.

The product includes the following:
• L Glutathione Reduced
• Vitamin B-12 (Methylcobalamine)
• Folate (as 5-MTHF)
• SAMe
• R-Alpha Lipoic Acid
• B-6 (as P5P)
• Magnesium (as Magnesium Orotate 7%)
• L-Selenomethionine
• Dandelion Leaf

Dr. Dale has changed the form of Folate and Selenium and quantity for enhanced absorption. Further important information about this product follows.

5-methyltetrahydrofolate (5-MTHF)

Is an Elevated level of Homocysteine Making You Sick?
A New Bioactive Form of Folic Acid Can Lower Stubbornly High Homocysteine when B Vitamins Fail!

5-methyltetrahydrofolate (5-MTHF) is the most biologically active form of the B-vitamin folic acid, also known generically as folate. 5-MTHF functions, in concert with vitamin B12, as a methyl-group donor involved in the conversion of the amino acid homocysteine to methionine. Methyl (CH3) group donation is vital to many bodily processes, including serotonin, melatonin, and DNA synthesis. Therapeutically, 5-MTHF is instrumental in reducing homocysteine levels, preventing neural tube defects, and improving vascular endothelial function. Research on folate supplementation suggests it plays a key role in preventing cervical dysplasia and protecting against neoplasia in ulcerative colitis. Folate also shows promise as part of a nutritional protocol to treat vitiligo, and may reduce inflammation of the gingiva. Furthermore, certain neurological, cognitive, and psychiatric presentations may be secondary to folate deficiency. Such presentations include depression, peripheral neuropathy, myelopathy, restless legs syndrome, insomnia, dementia, forgetfulness, irritability, endogenous depression, organic psychosis, and schizophrenia-like syndromes. 5-MTHF supplementation may be a more favorable method of folate repletion.

Folate deficiency is considered to be one of the most common nutritional deficiencies. The following may contribute to a deficiency of folic acid: deficient food supply; defects in utilization, as in alcoholics or individuals with liver disease; malabsorption; increased needs in pregnant women, nursing mothers, and cancer patients; metabolic interference by drugs; folate loss in hemodialysis; and deficiencies in enzymes or cofactors needed for the generation of active folic acid. Absorption of folic acid appears to be significantly impaired in HIV disease, irrespective of the stage of the disease. Signs and symptoms of folate deficiency include macrocytic anemia, inflammatory bowel disease, fatigue, irritability, peripheral neuropathy, tendon hyper-reflexivity, restless legs syndrome, diarrhea, weight loss, insomnia, depression, dementia, cognitive disturbances, and psychiatric disorders. Elevated plasma homocysteine can also indicate a dietary or functional deficiency of folic acid.

Elevated plasma homocysteine, the de-methylated derivative of the amino acid methionine, is an independent risk factor for cardiovascular disease. Hyperhomocysteinemia has been connected to increased risk of neural tube defects and other birth defects, as well as to schizophrenia, Alzheimer’s disease, cognitive decline, osteoporosis, rheumatoid arthritis, kidney failure, and cancer.

Folic acid reduces elevated liver enzymes induced by methotrexate therapy in rheumatoid arthritis; however, it had no effect on the incidence, severity, and duration of other adverse events. Folate supplementation prevents nitric oxide synthase dysfunction induced by continuous nitroglycerin use.

In doses typically administered for therapeutic purposes, 5-MTHF is considered non-toxic. At doses of up to 50 mg daily, gastrointestinal com-plaints, insomnia, irritability, and fatigue have been mentioned as occasional side effects. Folic acid and 5-MTHF are considered safe during pregnancy, with a recommended intake of 800 mcg daily.

A number of drugs can interfere with the pharmacokinetics of folic acid. Cimetidine and antacids appear to reduce folate absorption. Sulfasalazine interferes with folic acid absorption and conversion to 5-MTHF. Anti-seizure med’s and folic acid supplementation maybe contraindicated with Folate usage.


Selenium is an essential mineral; selenomethionine is an amino acid-based type of organic selenium found naturally in food. L-Selenomethionine is more easily absorbed than non-organic forms of selenium such as selenate. Methionine is an amino acid, meaning it is a building block of protein. When you consume selenomethionine supplements, your body recognizes the selenium as the amino acid methionine and immediately incorporates it in into its protein stores. In fact, taking selenomethionine supplements results in plasma selenium stores twice as high as equivalent doses of non-organic selenium supplements such as selenate, according to the Natural Medicines Comprehensive Database.

Selenomethionine is a potent antioxidant and immune system booster and it promotes both heart and liver health, state Phyllis Balch CNC and James Balch M.D., in their book “Prescription for Nutritional Healing.” Alternative health-care practitioners use selenium to help treat cardiovascular disease, a variety of cancers, chemotherapy toxicity, diabetes, macular degeneration, cataracts, hypothyroidism, autoimmune thyroiditis, osteoarthritis, rheumatoid arthritis, stroke, atherosclerosis, benign prostatic hyperplasia and critical illness. People also use selenium supplements such as selenomethionine to help treat avian flu, swine flu, HIV/AIDS, allergic rhinitis, infertility, gray hair, abnormal pap smears, chronic fatigue syndrome, mood disorders and arsenic poisoning. However, more research is needed to confirm the efficacy of selenomethionine supplements for these purposes.

Selenomethionine supplements may be useful for colon cancer patients, according to the July-August 2002 edition of “Cancer Biology and Therapy” journal. The journal tested the effects of selenomethionine on four different colon cancer cell lines, and selenomethionine inhibited the growth of all four. The study was preliminary, but concluded that selenomethionine shows promise for the prevention and treatment of colon cancer.

Note: For Adults, we recommend using our Nano Ionic Iodine and the Slow Cleanse along with this product. Please test dosages for adults and children.

Know Your Plastics

by Theresa Dale in Member Bonus Section

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