The Wellness Center for Research & Education, Inc. What’s the Difference Between Saliva, Urine & Serum Hormone Testing?

Bioactive hormonal fraction

• Saliva reflects the unbound bioactive hormone level to which living cells are subjected. This is the hormone level that needs to be evaluated.
• Real Life Hormone Function Evaluation.
• Multiple Salivary Specimens.
• Can be collected under real life situations, at work, at home, etc.
• Hormone values reflect real life physiological conditions and responses.
• Saliva is easily collected by the patient.
• Patient collects sample with minimal biohazard to clinic staff.
• Multiple saliva samples collected at different times allow evaluation of hormonal stress response and circadian rhythm.
Therapeutic discrimination
Because saliva testing can sub-classify hormonal dysfunction into time related values, the subclasses of dysfunction are discernable. Consequently, therapeutic options are expanded and treatments are very specific.

Urine Tests

• Urine hormones reflect production and catabolism and do not reflect tissue level hormone concentrations that living cells are exposed to. Urine hormone interpretation is very misleading.
• Urine testing results are reported as: high, low, or normal.
• Hormone values & treatment options are limited and not always synchronized and harmonious with the natural circadian cycle of the patient.
• 24 -hour urine has metabolites of the hormones and is not time specific and does not reflect time sensitive hormonal and stress responses.
• 24-hour urine collection is cumbersome and time consuming, especially for women.
• Urine collection is minimally bio-hazardous to clinic staff.
• 24-hour urine is absolutely time non-specific and does not reflect circadian rhythm variation at all.

Serum Tests

• Serum testing results are reported as: high, low, or normal.
• Hormone values & treatment options are limited and not always synchronized and harmonious with the natural circadian cycle of the patient.
• Routine serum hormone testing reflects total hormone level not the bioactive fraction. Total levels are crude estimates of unbound bioactive hormone.
• Serum collection requires clinic visit and creates apprehension  due to anticipation of venipuncture. Stess causes an artificial increase in cortisol.
• Only approximates real life conditions.
• Serum tests require clinic staff and disruption of routine schedule of patient.
• Serum collection is bio-hazardous to clinic staff especially with AIDS and Hepatitis.
• The routine single serum sample does not allow circadian rhythm evaluation, i.e., no real time component.

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