Toxins in Supplements

The Wellness Center For Research & Education, Inc;

© 2011 Dr. Theresa Dale, PhD, CCN, NP

If you are ingesting supplements to create a healthier body and mind, you need to know the facts about the supplement manufacturing process and labeling codes.

Are your supplements healthy or toxic?

Did you know that the binders, fillers, heavy metals and flow agents in your supplements are harmful? I have ongoing research to report that may shock and disappoint you. Due to the fact that supplement manufacturers for the most part are numb to the fact that additives and excipents in vitamins and minerals cause health issues, we need to go beyond reading labels and read the laws. Labeling laws state that if as product has less than 5 ppm of heavy metals, flow agent, filler, binder (excipents); they don’t have to be disclosed on the label. Shocking but true! Moreover, just because these additives are not listed on the label doesn’t mean that the products do not contain them. Lets take a look at some of the worst ingredients in supplements today.

The facts about these egregious ingredients, which are shown to cause health problems are shocking but hopefully it will allow you to choose your supplements wisely and ask questions.

Magnesium Stearate, Stearic Acid And Calcium Stearate

These stearates, made by hydrogenating cottonseed or palm oil, are used throughout the supplement industry as lubricants. They are added to the raw materials in supplements so that production machinery will run at maximum speeds. These fatty substances coat every particle of the nutrients, so the particles will flow rapidly. This ensures that production schedules will meet profit targets.

Cottonseed oil has the highest content of pesticide residues of all commercial oils; cotton crops are heavily sprayed. In the hydrogenation process, the oil is subjected to high heat and pressure in the presence of a metal catalyst for several hours, creating a hydrogenated saturated fat. Hydrogenated vegetable fats contain altered molecules derived from fatty acids that may be toxic. The metal catalyst used in the hydrogenation process may also contaminate the stearates produced (see Erasmus, Fats and Oils).

While toxicity is one problem, decreased absorption is another. In a study published in the journal Pharmaceutical Technology, the percent dissolution for capsules after 20 minutes in solution went from 90% without stearates to 25% with stearates. Clearly, stearates reduced the rate the capsule dissolved by 65%! This delays the absorption of nutrients. Individuals with impaired digestion may have particular difficulty absorbing nutrients coated with stearates.

Other problems with Magnesium Stearate and Other Stearates.

Concentrated doses of stearic acid suppress the action of T-cells, a key component of the immune system. The article “Molecular basis for the immunosuppressive action of stearic acid on T cells” appeared in the journal Immunology in 1990.

Did you know that…

  • Companies that manufacture and transport magnesium stearate must file a Material Safety Data Sheet with the Environmental Protection Agency because concentrated magnesium stearate is classified as a hazardous substance.
  • Its uses are listed as “ammunition, dusting powder, paint and varnish drier, binder, and emulsifier.” The section “Human Health Data” states that “Inhalation may irritate the respiratory tract” and “Acute ingestion may cause gastroenteritis.”
  • Under the heading “Regulatory Information,” the paper states, “This product is hazardous under the criteria of the Federal OSHA Hazard Communication Standard.” This information may be viewed at the web site: This document is indeed confusing for consumers due to the fact that OSHA contradicts their own reporting. The above url states the following information.

Section XI. Toxicological Information

  • RTECS Number: Not Established
  • Routes of Exposure: Eye contact. Ingestion. Inhalation. Skin contact.
  • Toxicity Data: To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated for Magnesium Stearate.
  • Chronic Toxic Effects: This product has no known chronic effects. Repeated or prolong exposure to this compound is not known to aggravate medical conditions.
  • Acute Toxic Effects: Irritating to the skin and eyes on contact. Inhalation will cause irritation to the lungs and mucus membrane. Irritation to the eyes will cause watering and redness. Reddening, scaling, and itching are characteristics of skin inflammation. Follow safe industrial hygiene practices and always wear protective equipment when handling this compound.

Immune System

Excessive ingestion of magnesium stearate adversely affects the normal functioning of T-cells, which are very important for the body’s immune responses. High amounts of magnesium stearate act as a immunosuppressor. Thus, prolonged administering of magnesium stearate at a high dosage weakens the immune system over a period of time.

Absorption Decreased

One of the reported dangers of magnesium stearate is the decreased absorption of Vitamin B2, B3, Vitamin A, Vitamin E, and Zinc. Researchers report that tablets without magnesium stearate have a 90 percent absorption rate, while those formated with magnesium stearate show a 25-30 percent absorption capacity. This is the reason why, some people complain of absorption problems after taking magnesium stearate containing products. This would be very serious in a person with a health issue, as it would be compounding the problem.

Supplement manufacturers pass off magnesium stearate as a benign form of magnesium. Magnesium stearate is the magnesium salt of stearic acid, which is also used in supplements for the same purposes. The argument is made that small amounts of these substances do no harm. But do you really want them in your supplements every day? Remember, the sole purpose of using these substances is a flow agent ~ to make the machines go faster. Supplements can be made without them; it just takes more time, care, and attention to detail.

How Much Hydrogenated Lubricant Oils Are You Getting With Your Supplements?

Up to 5% of the average 1000 mg capsule or tablet is magnesium stearate. That’s 50 milligrams. Suppose you take 8 capsules or tablets a day. That’s 250 a month – or 12,500 mg of this hydrogenated oil, nearly half an ounce. That works out to about 6 ounces of hydrogenated oils a year, from just 8 pills a day. Many people take more supplements, and ingest pounds of this toxic oil we try to avoid in our diets – while directly inhibiting the utilization of the nutrients they’re supplementing!

Remember, the sole purpose of using these oils is to make the machines go faster. Supplements can be made without them – it just takes more time, care and attention to detail. Our exclusive process yields absolutely pure supplements – no lubricants, binders, flowing agents, fillers, dyes or additives of any kind – only the pure nutrients.

Aspartame Side Effects

There are over 92 different health side effects associated with aspartame consumption. It seems surreal, but true. How can one chemical create such chaos?

Aspartame dissolves into solution and can therefore travel throughout the body and deposit within any tissue. The body digests aspartame unlike saccharin, which does not break down within humans.

The multitudes of aspartame side effects are indicative to your genetic individuality and physical weaknesses. It is important to identify which side effects aspartame is creating within you.

Aspartame Side Effects: Grave Disease or Aspartame Poisoning.

The components of aspartame can lead to a number of health problems, as you have read. Side effects can occur gradually, can be immediate, or can be acute reactions.

According to Lendon Smith, M.D. there is an enormous population suffering from side effects associated with aspartame, yet have no idea why drugs, supplements and herbs don’t relieve their symptoms.

Then, there are users who don’t ‘appear’ to suffer immediate reactions at all. The answer is that the aspartame builds up in the body. Even individuals who don’t have current side effects are susceptible to the long-term damage caused by excitatory amino acids, phenylalanine, methanol, and DKP.

Adverse reactions and side effects of aspartame include:


  • blindness in one or both eyes
  • decreased vision and/or other eye problems such as: blurring, bright flashes, squiggly lines, tunnel vision,
  • decreased night vision
  • pain in one or both eyes
  • decreased tears
  • trouble with contact lenses
  • bulging eyes


  • tinnitus – ringing or buzzing sound
  • severe intolerance of noise
  • marked hearing impairment


  • epileptic seizures
  • headaches, migraines and (some severe)
  • dizziness, unsteadiness, both
  • confusion, memory loss, both
  • severe drowsiness and sleepiness
  • paresthesia or numbness of the limbs
  • severe slurring of speech
  • severe hyperactivity and restless legs
  • atypical facial pain
  • severe tremors


  • severe depression
  • irritability
  • aggression
  • anxiety
  • personality changes
  • insomnia
  • phobias


  • palpitations, tachycardia
  • shortness of breath
  • recent high blood pressure


  • nausea
  • diarrhea, sometimes with blood in stools
  • abdominal pain
  • pain when swallowing
  • Skin and Allergies
  • itching without a rash
  • lip and mouth reactions
  • hives
  • aggravated respiratory allergies such as asthma

Endocrine and Metabolic

  • loss of control of diabetes
  • menstrual changes
  • marked thinning or loss of hair
  • marked weight loss
  • gradual weight gain
  • aggravated low blood sugar (hypoglycemia)
  • severe PMS
  • Other
  • frequency of voiding and burning during urination
  • excessive thirst, fluid retention, leg swelling, and bloating
  • increased susceptibility to infection

Additional Symptoms of Aspartame Toxicity include the most critical symptoms of all

  • irreversible brain damage
  • birth defects, including mental retardation
  • peptic ulcers
  • aspartame addiction and increased craving for sweets
  • hyperactivity in children
  • severe depression
  • aggressive behavior
  • suicidal tendencies

Aspartame may trigger, mimic, or cause the following illnesses:

  • Chronic Fatigue Syndrome
  • Epstein-Barr
  • Post-Polio Syndrome
  • Lyme Disease
  • Grave’s Disease
  • Meniere’s Disease
  • Alzheimer’s Disease
  • ALS
  • Epilepsy
  • Multiple Sclerosis (MS)
  • EMS
  • Hypothyroidism
  • Fibromyalgia
  • Lupus
  • non-Hodgkins Lymphoma
  • Attention Deficit Disorder (ADD)

These are NOT allergies or sensitivities, but diseases and disease syndromes. Aspartame poisoning is commonly misdiagnosed because aspartame symptoms mock textbook ‘disease’ symptoms, such as Grave’s Disease.

Aspartame changes the ratio of amino acids in the blood, blocking or lowering the levels of serotonin, tyrosine, dopamine, norepinephrine, and adrenaline. Therefore, it is typical that aspartame symptoms cannot be detected in lab tests and on x-rays. Textbook disorders and diseases may actually be a toxic load as a result of aspartame poisoning.

Have you ever gone to the doctor with real, physical symptoms, but they can’t find the cause? Well, it’s probably your diet, your environment or emotions.

Aspartame is the common denominator for over 92 different health symptoms at the root of modern disease.

The Aspartame and Sucralose Detoxification Program is the most effective way to reverse disease symptoms.

  • Remove all sugar-free products with aspartame and sucralose from your diet.
  • Read Labels
  • Get a Five Element Saliva Test and a hair analysis.
  • Detoxify using the Dr. Dale’s Slow Cleanse for 30 days.
  • Restore depleted nutrients with Dr. Dale’s Optimal Multi and Nano Ionic Multi.
  • Exercise and get plenty of rest.
  • Eat 75% raw foods at every meal.
  • Drink water, water, water.

Sucralose Toxicity: (Splenda)

According to one source (Sucralose Toxicity Information Center), concerning the significant reduction in size of the thymus gland, “the manufacturer claimed that the sucralose was unpleasant for the rodents to eat in large doses and that starvation caused the shruken thymus glands.

Toxicologist Judith Bellin reviewed studies on rats starved under experimental conditions, and concluded that their growth rate could be reduced by as much as a third without the thymus losing a significant amount of weight (less than 7 percent). The changes were much more marked in rats fed on sucralose. While the animals’ growth rate was reduced by between 7 and 20 percent, their thymuses shrank by as much as 40 percent. (New Scientist 23 Nov 1991, pg 13)”

Research in animals has shown that sucralose can cause many problems in rats, mice, and rabbits, such as:

  • Shrunken thymus glands (up to 40% shrinkage)
  • Enlarged liver and kidneys
  • Atrophy of lymph follicles in the spleen and thymus
  • Increased cecal weight
  • Reduced growth rate
  • Decreased red blood cell count
  • Hyperplasia of the pelvis
  • Extension of the pregnancy period
  • Aborted pregnancy
  • Decreased fetal body weights and placental weights

The most misunderstood fact about sucralose is that it is nothing like sugar even though the marketing implies that it is. Sucralose was actually discovered while trying to create a new insecticide. It may have started out as sugar, but the final product is anything but sugar. According to the book Sweet Deception, sucralose is made when sugar is treated with trityl chloride, acetic anhydride, hydrogen chlorine, thionyl chloride, and methanol in the presence of dimethylformamide, 4-methylmorpholine, toluene, methyl isobutyl ketone, acetic acid, benzyltriethlyammonium chloride, and sodium methoxide, making it unlike anything found in nature. If you read the fine print on the Splenda web site, it states that “although sucralose has a structure like sugar and a sugar-like taste, it is not natural.”

The name sucralose is misleading. The suffix -ose is used to name sugars, not additives. Sucralose sounds very close to sucrose, table sugar, and can be confusing for consumers. A more accurate name for the structure of sucralose was purposed. The name would have been trichlorogalactosucrose, but the FDA did not believe that it was necessary to use this so sucralose was allowed.

The presence of chlorine is thought to be the most dangerous component of sucralose. Chlorine is considered a carcinogen and has been used in poisonous gas, disinfectants, pesticides, and plastics. The digestion and absorption of sucralose is not clear due to a lack of long-term studies on humans. The majority of studies were done on animals for short lengths of time. The alleged symptoms associated with sucralose are gastrointestinal problems (bloating, gas, diarrhea, nausea), skin irritations (rash, hives, redness, itching, swelling), wheezing, cough, runny nose, chest pains, palpitations, anxiety, anger, moods swings, depression, and itchy eyes. The only way to be sure of the safety of sucralose is to have long-term studies on humans done.

Splenda is a product that contains the artificial sweetener sucralose, but that is not all that it contains. Sucralose does have calories, but because it is 600 times sweeter than sugar, very small amounts are needed to achieve the desired sweetness so you most likely won’t consume enough to get any calories. The other two ingredients in Splenda are dextrose and maltodextrin, which are used to increase bulk and are carbohydrates that do have calories. One cup of Splenda contains 96 calories and 32 grams of carbohydrates, which is often unnoticed due to the label claiming that it’s a no calorie sweetener. Because this is found in so many products and can be used in cooking, it can be possible to consume 1 cup or more each day. For people with diabetes, this is a significant amount of carbohydrates, and for people who are watching their weight, this can be a problem. Consuming an additional 100 calories a day can result in a weight gain of 10 lbs. per year!

A recent study found that Splenda affected the absorption of medications in rats. The rats were given sucralose at doses of 1.1-11 mg/kg. After 12-weeks, they found that the rats had half of the good bacteria in the gut. They also found that Splenda interferes with the absorption of prescription medications. Other research studies have come out to show that this is not what happens. The only way to know for sure is to perform long-term studies in humans. Unfortunately, this takes time. It can also be dangerous if this is actually happening. The limited number of studies and lack of long-term studies on sucralose means that we are going to have to learn things like this as we go.

MINNEAPOLIS, Sept. 22, 2008 (GLOBE NEWSWIRE) — James Turner, chairman of the national consumer education group Citizens for Health expressed shock and outrage after reading a new report from scientists at Duke University. “The report makes it clear that the artificial sweetener Splenda and its key component sucralose pose a threat to the people who consume the product. Hundreds of consumers have complained to us about side effects from using Splenda and this study, published this past week in the Journal of Toxicology and Environmental Health Part A, confirms that the chemicals in the little yellow package should carry a big red warning label,” said Turner.

Among the results in the study by Drs. Mohamed B. Abou-Donia, Eman M. El-Masry, Ali A. Abdel-Rahman, Roger E. McLendon and Susan S. Schiffman is evidence that, in the animals studied, Splenda reduces the amount of good bacteria in the intestines by 50%, increases the pH level in the intestines, contributes to increases in body weight and affects the P-glycoprotein (P-gp) in the body in such a way that crucial health-related drugs could be rejected. Turner noted that the P-gp effect “could result in crucial medications used in chemotherapy for cancer patients, AIDS treatment and drugs for heart conditions being shunted back into the intestines rather than being absorbed by the body as intended.”


Both aspartame and sucralose appear to trigger headaches in some individuals, according to research studies. A 2006 study published in the scholarly journal “Headache,” notes that sucralose triggers migraine headaches in some users. Another study published in “Headache” — this one conducted in 2005 — indicates similar effects from aspartame. If you find that you’re having unexplained headaches and use either sucralose or aspartame, you might try removing the artificial sweetener from your diet for a period of several days. If the headaches resolve, it may be that the sweeteners were causing your symptoms.

Increased Sweet Cravings

Studies have linked consumption of sweet food to increased desire for sweet food. As such, if you consistently sweeten your food — whether you use table sugar, honey or a non-caloric sweetener such as aspartame or sucralose — you may crave sweet flavors more than you otherwise would. A 1988 study published in the scholarly journal “Physiology and Behavior,” reports that individuals who consume non-nutritive sweeteners crave sugar more than those who don’t use these sweeteners. Researchers suggest that because artificial sweeteners are much sweeter than table sugar, they increase desire for very sweet flavors.

Cancer Risk

Sucralose is one of the newest artificial sweeteners, and, as of 2010, no studies have linked use of the sweetener to cancer risk. However, a 2007 article in the scholarly journal “Environmental Health Perspectives,” notes that rats exposed to aspartame in utero have a higher risk of cancer over the course of their lives. This may or may not indicate that using aspartame as an adult will increase your risk of cancer, but it does suggest that if you are pregnant, using aspartame during your pregnancy might make it more likely that your unborn child will have a higher risk of cancer later in life.

Abdominal Cramping

One of the most common complaints from Splenda is abdominal cramping, bloating and pain that often resembles a pulled muscle, food borne illness or more serious gastronomical problems. It often takes awhile for most people to form a connection to something they ate with Splenda. But once they realize that is the culprit, people with this reaction are more diligent about checking labels and avoiding the sweetener altogether


With symptoms ranging from mild headaches to migraines, Splenda has long been blamed for headaches in many people. For most people experiencing this symptom, the results begin within minutes of drinking a beverage or other product containing Splenda and can last for hours. For most people, the symptoms stop within 24 hours after Splenda is cut from their diet.

Mood Swings

Many people who eat Splenda regularly have suffered from immense mood swings, but have had a tough time putting the connection between the mood swings and Splenda together. Because many people using Splenda are dieting and trying to lose weight, they often attribute the mood swings to other influences. But once they cut Splenda from their diet, they realize that the mood swings are alleviated altogether.

Weight Gain

Though Splenda was developed as an alternative to sugar with fewer calories, for many Splenda has caused weight gain. Whether it is a combination of bloating, overindulgence, or a direct result of ingesting sucralose, many people have found that it is easier to lose weight when cutting out sweets altogether instead of just replacing the natural sugar with an artificial one.


There have been many reports of people experiencing chronic fatigue after consuming products made with sucralose. In most cases, this fatigue and overall sleepiness is alleviated within a day or two of ceasing to eat products made with Splenda. The fatigue has been characterized by many symptoms, ranging from an overall sleepiness, to an inability to concentrate or focus, to a tingling and weakness in the limbs for hours after eating something containing sucralose.

With so many potential side effects, it is no wonder that many are leery about using Splenda. Everyone’s body is different though, and many people experience no symptoms. At any rate, it is a good idea to keep track of when you ingest Splenda to determine if some of the side effects you may be experiencing are from Splenda, and if so, cut it from your diet.

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