What’s the Difference Between Saliva, Urine & Serum Hormone Testing?

Bioactive hormonal fraction

•    Saliva reflects the unbound bioactive hormone level to which

living cells are subjected. This is the hormone level that needs to be evaluated.

•    Real Life Hormone Function Evaluation.

•    Multiple Salivary Specimens.

•    Can be collected under real life situations, at work, at home, etc.

•    Hormone values reflect real life physiological conditions and responses.

•    Saliva is easily collected by the patient.

•    Patient collects sample with minimal biohazard to clinic staff.

•    Multiple saliva samples collected at different times allow evaluation of hormonal stress response and circadian rhythm.

Therapeutic discrimination

Because saliva testing can sub-classify hormonal dysfunction into time related values, the subclasses of dysfunction are discernable. Consequently, therapeutic options are expanded and treatments are very specific.

Urine Tests

•    Urine hormones reflect production and catabolism and do not reflect tissue level hormone concentrations that living cells are exposed to. Urine hormone interpretation is very misleading.

•    Urine testing results are reported as: high, low, or normal.

•    Hormone values & treatment options are limited and not always synchronized and harmonious with the natural circadian cycle of the patient.

•    24 -hour urine has metabolites of the hormones and is not time specific and does not reflect time sensitive hormonal and stress responses.

•    24-hour urine collection is cumbersome and time consuming, especially for women.

•    Urine collection is minimally bio-hazardous to clinic staff.

•    24-hour urine is absolutely time non-specific and does not reflect circadian rhythm variation at all.

Serum Tests

•    Serum testing results are reported as: high, low, or normal.

•    Hormone values & treatment options are limited and not always synchronized and harmonious with the natural circadian cycle of the patient.

•    Routine serum hormone testing reflects total hormone level not the bioactive fraction. Total levels are crude estimates of unbound bioactive hormone.

•    Serum collection requires clinic visit and creates apprehension due to anticipation of venipuncture. Stess causes an artificial

increase in cortisol.

•    Only approximates real life conditions.

•    Serum tests require clinic staff and disruption of routine schedule of patient.

•    Serum collection is bio-hazardous to clinic staff especially with

AIDS and Hepatitis.

•          The routine single serum sample does not allow circadian rhythm evaluation, i.e., no real time component

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